Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas

被引：0
|
作者：
Yi Wei
Chen Jian
Filimon H. Golwa
Xue Delin
机构：
[1] Huazhong University of Science and Technology,Department of Neurosurgery, Tongji Hospital, Tongji Medical College
来源：
Current Medical Science | 2005年 / 25卷 / 1期
关键词：
meningiomas; basic fibroblast growth factor; fibroblast growth factor receptor-1; microvascular density; immunohistochemistry;
D O I：
10.1007/BF02831392
中图分类号：
学科分类号：
摘要：
The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. the tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.
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页码：75 / 77
页数：2
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