Vitamin A supplementation in early life affects later response to an obesogenic diet in rats

被引:0
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作者
N Granados
J Amengual
J Ribot
H Musinovic
E Ceresi
J von Lintig
A Palou
M L Bonet
机构
[1] Laboratory of Molecular Biology,Department of Pharmacology
[2] Nutrition and Biotechnology-Nutrigenomics,undefined
[3] University of the Balearic Islands and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn),undefined
[4] School of Medicine,undefined
[5] Case Western Reserve University,undefined
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关键词
vitamin A; early life nutrition; programming; adiposity; high-fat diet;
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摘要
This paper reports that rats that are given excess vitamin A (three times normal requirement) in early life become more obese than control animals when given a high-fat diet later in life. Although this is an animal study, it is worth considering the implications for humans. Some children are given extra vitamins in early life and modern civilization provides a high fat, obesogenic environment throughout life. Further research in humans is needed to identify individuals who were given excess vitamin A in early life to determine if they are at higher risk of subsequent obesity.
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页码:1169 / 1176
页数:7
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