Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

被引:0
|
作者
Melanie Wencker
Gleb Turchinovich
Rafael Di Marco Barros
Livija Deban
Anett Jandke
Andrew Cope
Adrian C Hayday
机构
[1] London Research Institute,Peter Gorer Department of Immunobiology
[2] Cancer Research UK,undefined
[3] King's College London,undefined
[4] University College London,undefined
[5] Centre for the Molecular and Cell Biology of Inflammation,undefined
[6] King's College London,undefined
[7] Present address: Department of Biomedicine,undefined
[8] University of Basel,undefined
[9] Basel,undefined
[10] Switzerland.,undefined
来源
Nature Immunology | 2014年 / 15卷
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摘要
T cell hyporesponsiveness is generally framed in terms of tolerance induction. Hayday and colleagues show that attenuating TCR responsiveness is also critical for the development of innate-like T cells that mediate the surveillance of dysregulated tissues.
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页码:80 / 87
页数:7
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