Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

被引：0
|
作者：
Jacqueline M. Kimmey
Jeremy P. Huynh
Leslie A. Weiss
Sunmin Park
Amal Kambal
Jayanta Debnath
Herbert W. Virgin
Christina L. Stallings
机构：
[1] Washington University School of Medicine,Department of Molecular Microbiology
[2] Washington University School of Medicine,Department of Pathology and Immunology
[3] University of California,Department of Pathology and Helen Diller Family Comprehensive Cancer Center
[4] San Francisco,undefined
来源：
Nature | 2015年 / 528卷
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摘要：
Genetic engineering in mice reveals that autophagy is not an essential mechanism in myeloid cells for controlling Mycobacterium tuberculosis infection, and that autophagy factor ATG5 protects organisms by regulating neutrophil influx and tissue damage.
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页码：565 / 569
页数：4
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