Effect of FTY720 and ICAM-1 mAb mono and combination therapy in cardiac allo-transplantation in rats

被引：0
|
作者：
Hai-bo Xiong
Zu-fa Huang
Sui-sheng Xia
Qi-fa Ye
Hao Wen
机构：
[1] Central South University,Institute of Transplantation, the Third Xiangya Hospital
[2] Xinjiang Medical University,Department of General Surgery, the First Affiliated Hospital
[3] Tongji Hospital of Huazhong Science and Technological University,Institute of Transplantation
来源：
Journal of Central South University of Technology | 2005年 / 12卷
关键词：
FTY720; ICAM-1 mAb; synergy; rat; heart transplantation; immune tolerance; rejection; R392.4;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective To observe the effect of FTY720 and ICAM-1 mAb mono and combination therapy in cardiac allo-transplantation in rats. Methods Rats were randomly assigned to 9 groups, heart allo-transplantation were performed in abdominal site with micro-surgical technique. Recipients with allografts were treated with different doses of FTY720 and (or) ICAM-1 mAb. Graft survival, histopathology and level of serum IL-2, IFN-γ, IL-4, IL-10 were investigated. Results Low doses of FTY720 (1mg/kg) combined with ICAM-1 mAb achieved synergistic effect in the prolongation of cardiac graft survival, combination index(CI)=0.67. Conclusion Concomitant therapy of FTY720 and ICAM-1 mAb achieved a synergistic effect in the prolongation of heart allograft survival in rats.
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页码：343 / 346
页数：3
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