Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPARγ agonists

被引：0
|
作者：
Raok Jeon
Yoon-Jung Kim
Yejin Cheon
Jae-Ha Ryu
机构：
[1] Sookmyung Women's University,College of Pharmacy
来源：
Archives of Pharmacal Research | 2006年 / 29卷
关键词：
Benzothiazole; Thiazolidinediones; PPARγ; Nitric oxide; Diabetes;
D O I：
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学科分类号：
摘要：
Benzothiazole derivatives of thiazolidinediones (TZD) were synthesized using a modified Mitsunobu reaction of 2-(benzothiazol-2-ylmethylamino)ethanol (2) with 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione and assayed for activity on peroxisome proliferator-activated receptor (PPAR) subtypes and inhibitory activity of NO production in lipopolysaccharide-activated macrophages. Most of the tested compounds were identified as potent PPARγ agonists, indicating their potential as drug candidates for diabetes.
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