Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

被引：0
|
作者：
Benjamin G Hoffstrom
Anna Kaplan
Reka Letso
Ralf S Schmid
Gregory J Turmel
Donald C Lo
Brent R Stockwell
机构：
[1] Howard Hughes Medical Institute,Department of Biological Sciences
[2] Columbia University,Center for Drug Discovery and Department of Neurobiology
[3] Duke University Medical Center,Department of Chemistry
[4] Columbia University,undefined
来源：
Nature Chemical Biology | 2010年 / 6卷
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摘要：
Expression of a Huntington's-disease variant of huntingtin protein causes accumulation of the chaperone protein disulfide isomerase. This protein is the target of compounds obtained from screening for those that can alleviate cell death promoted by the mutant huntingtin, and represents a new connection between protein misfolding and cell death.[graphic not available: see fulltext]
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页码：900 / 906
页数：6
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