Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

被引：0

作者：

Alessandro Filosa

Sónia Paixão

Silke D Honsek

Maria A Carmona

Lore Becker

Berend Feddersen

Louise Gaitanos

York Rudhard

Ralf Schoepfer

Thomas Klopstock

Klas Kullander

Christine R Rose

Elena B Pasquale

Rüdiger Klein

机构：

[1] Max Planck Institute of Neurobiology,Department of Molecular Neurobiology

[2] Institute for Neurobiology,Department of Neurology

[3] Heinrich Heine University Düsseldorf,Department of Neuroscience

[4] Burnham Institute for Medical Research,undefined

[5] German Mouse Clinic,undefined

[6] Institute of Experimental Genetics,undefined

[7] Helmholtz Center,undefined

[8] German Research Center for Environmental Health (GmbH),undefined

[9] Friedrich Baur Institute,undefined

[10] University of Munich,undefined

[11] Laboratory for Molecular Pharmacology,undefined

[12] University College London,undefined

[13] Uppsala University,undefined

[14] Present address: Evotec AG,undefined

[15] Hamburg,undefined

[16] Germany.,undefined

来源：

Nature Neuroscience | 2009年 / 12卷

关键词：

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学科分类号：

摘要：

The authors show long-term potentiation at the hippocampal CA3–CA1 synapse is modulated by EphA4 in the postsynaptic CA1 neuron and by ephrin-A3, an EphA4 ligand, in astrocytes, through their regulation of glial glutamate transporters. These results suggest EphA4/ephrin-A3 signaling as a mechanism for astrocytic regulation of synaptic plasticity.

引用

页码：1285 / 1292

页数：7

共 8 条

[1] Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Filosa, Alessandro
Paixao, Sonia
Honsek, Silke D.
Carmona, Maria A.
Becker, Lore
Feddersen, Berend
Gaitanos, Louise
Rudhard, York
Schoepfer, Ralf
Klopstock, Thomas
Kullander, Klas
Rose, Christine R.
Pasquale, Elena B.
Klein, Ruediger
NATURE NEUROSCIENCE, 2009, 12 (10) : 1285 - U106
[2] Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Murai, KK
Nguyen, LN
Irie, F
Yamaguchi, Y
Pasquale, EB
NATURE NEUROSCIENCE, 2003, 6 (02) : 153 - 160
[3] Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Keith K. Murai
Louis N. Nguyen
Fumitoshi Irie
Yu Yamaguchi
Elena B. Pasquale
Nature Neuroscience, 2003, 6 : 153 - 160
[4] Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport
Carmona, Maria A.
Murai, Keith K.
Wang, Lei
Roberts, Amanda J.
Pasquale, Elena B.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (30) : 12524 - 12529
[5] Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery
Roig, Maria Neus Ballester
Roy, Pierre-Gabriel
Hannou, Lydia
Delignat-Lavaud, Benoit
Guerrier, Thomas-Andrew Sully
Belanger-Nelson, Erika
Dufort-Gervais, Julien
Mongrain, Valerie
CHRONOBIOLOGY INTERNATIONAL, 2023, 40 (08) : 983 - 1003
[6] Neuron-glia interaction via Drosophila CAM Klingon modulates Repo-mediated glial gene expression required for long-term memory formation
Matsuno, Motomi
Saitoe, Minoru
NEUROSCIENCE RESEARCH, 2011, 71 : E183 - E183
[7] EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and-B3
Brors, D
Bodmer, D
Pak, K
Aletsee, C
Schäfers, M
Dazert, S
Ryan, AF
JOURNAL OF COMPARATIVE NEUROLOGY, 2003, 462 (01) : 90 - 100
[8] Cognitive-exercise dual-task promotes cognitive function recovery in chronic cerebral ischemia male rats through regulating PI3K/Akt signaling pathway via inhibition of EphrinA3/EphA4
Zhang, Rong
Tao, Xue
Sun, Ruifeng
Dai, Tengteng
Xi, Xiaoshuang
Sun, Weishuang
Song, Li
Gong, Weijun
JOURNAL OF NEUROSCIENCE RESEARCH, 2024, 102 (01)

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