Effects of Bone Marrow Multipotent Mesenchymal Stromal Cells and Their Secretion Products on the Cellular Composition of the Thymus and Spleen of Female Wistar Rats with Experimental Chronic Inflammation of the Internal Genitals

被引：0
|
作者：
T. I. Dergacheva
A. V. Shurlygina
E. V. Mel’nikova
O. B. Gritsyk
M. V. Tenditnik
O. V. Poveshchenko
V. I. Konenkov
机构：
[1] Research Institute of Clinical and Experimental Lymphology,
[2] Research Institute of Physiology and Basic Medicine,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 164卷
关键词：
multipotent mesenchymal stromal cells; lymphocytes; inflammation; thymus; spleen;
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学科分类号：
摘要：
The effects of bone marrow multipotent mesenchymal stromal cells and their secretion products on the subpopulation composition of thymic and splenic lymphocytes were studied in female Wistar rats with experimental chronic inflammatory process in the internal genitals. Stromal cells and medium conditioned by these cells in different administration routes (intravenous or lymphotropic injection) produces different modulating effect on blood leukocyte count and on subpopulation composition of the splenic and thymic lymphocytes. The most manifest anti-inflammatory effect was observed after lymphotropic injection of multipotent mesenchymal stromal cells creating a high concentration and long persistence of the factors produced by these cells in the focus of inflammation.
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页码：75 / 79
页数：4
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