No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects

被引：0
|
作者：
Valentin Demmel
Anne Sandberg-Schaal
Jacob B. Jacobsen
Georg Golor
Jonas Pettersson
Anne Flint
机构：
[1] Nabios GmbH,Clinical Pharmacology
[2] Novo Nordisk A/S,Biostatistics
[3] Novo Nordisk A/S,Early Phase Clinical Unit
[4] PAREXEL International GmbH,Medical and Science
[5] Novo Nordisk A/S,undefined
来源：
Diabetes Therapy | 2018年 / 9卷
关键词：
Cardiac repolarization; Drug safety; GLP-1 receptor agonist; GLP-1 analog; QT interval; Semaglutide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1441 / 1456
页数：15
相关论文
共 50 条
  • [1] No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects
    Demmel, Valentin
    Sandberg-Schaal, Anne
    Jacobsen, Jacob B.
    Golor, Georg
    Pettersson, Jonas
    Flint, Anne
    [J]. DIABETES THERAPY, 2018, 9 (04) : 1441 - 1456
  • [2] Absence of QTc prolongation with semaglutide: a thorough QT/QTc study in healthy subjects
    Demmel, V.
    Sandberg-Schaal, A.
    Jacobsen, J. B.
    Golor, G.
    Flint, A.
    Pettersson, J.
    [J]. EUROPEAN HEART JOURNAL, 2017, 38 : 1128 - 1129
  • [3] No QTc Prolongation With Zanubrutinib: Results of Concentration-QTc Analysis From a Thorough QT Study in Healthy Subjects
    Mu, Song
    Darpo, Borje
    Tang, Zhiyu
    Novotny, William
    Tawashi, Manal
    Xue, Hongqi
    Willett, Michael
    Lin, Leo
    Sahasranaman, Sri
    Ou, Ying C.
    [J]. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2020, 13 (05): : 923 - 931
  • [4] Randomized, Controlled, Thorough QT/QTc Study Shows Absence of QT Prolongation with Luseogliflozin in Healthy Japanese Subjects
    Kumagai, Yuji
    Hasunuma, Tomoko
    Sakai, Soichi
    Ochiai, Hidekazu
    Samukawa, Yoshishige
    [J]. PLOS ONE, 2015, 10 (10):
  • [5] CONFIRMATION OF QT PROLONGATION BY ORAL MOXIFLOXACIN IN HEALTHY JAPANESE SUBJECTS FOR THOROUGH QT/QTC STUDIES IN JAPAN
    Kumagai, Y.
    Ikeda, Y.
    Fujita, T.
    Sahashi, K.
    Saikawa, T.
    [J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2011, 109 : 102 - 102
  • [6] Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects
    Dixon, Ruth
    Job, Sarah
    Oliver, Ruth
    Tompson, Debra
    Wright, John G.
    Maltby, Kay
    Lorch, Ulrike
    Taubel, Jorg
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 66 (03) : 396 - 404
  • [7] Albiglutide Does Not Prolong the QTc Interval in Healthy Subjects: A Thorough QT/QTc Study
    Darpo, Borje
    Zhou, Meijian
    Matthews, Jessica
    Zhi, Hui
    Perry, Caroline R.
    Reinhardt, Rickey
    [J]. DIABETES, 2013, 62 : A269 - A269
  • [8] Absence of QTc Prolongation with Buprenorphine/Samidorphan Combination: A Thorough QT/QTc (tQT) Study in Healthy Volunteers
    Lu, Hong
    Hard, Marjie
    Kleiman, Robert
    Liu, Wenlei
    Bergsma, Tim
    Stanford, Arielle D.
    Nangia, Narinder
    von Moltke, Lisa
    [J]. NEUROPSYCHOPHARMACOLOGY, 2018, 43 : S141 - S142
  • [9] Cagrilintide is not associated with clinically relevant QTc prolongation: A thorough QT study in healthy participants
    Gabe, Maria B. N.
    Fuhr, Rainard
    Sinn, Angela
    Eliasen, Astrid
    Berthelsen, Kasper K.
    Kuhlman, Anja B.
    Baekdal, Tine A.
    Nejad, Ayna B.
    [J]. DIABETES OBESITY & METABOLISM, 2024,
  • [10] A Thorough QT/QTc Study of Clobazam in Healthy Volunteers
    Tolbert, Dwain
    Gordon, Judy
    Harris, Stuart
    Walzer, Mark
    Bekersky, Ihor
    Reid, Susan
    [J]. CLINICAL THERAPEUTICS, 2017, 39 (10) : 2073 - 2086
12345