Structure of the 30S translation initiation complex

被引：0

作者：

Angelita Simonetti

Stefano Marzi

Alexander G. Myasnikov

Attilio Fabbretti

Marat Yusupov

Claudio O. Gualerzi

Bruno P. Klaholz

机构：

[1] Institute of Genetics and of Molecular and Cellular Biology,Department of Structural Biology and Genomics

[2] Inserm,Department of Biology MCA

[3] U596,undefined

[4] Illkirch F-67404,undefined

[5] France ,undefined

[6] CNRS,undefined

[7] UMR7104,undefined

[8] Illkirch F-67404,undefined

[9] France ,undefined

[10] Université Louis Pasteur,undefined

[11] Architecture et Réactivité de l’ARN,undefined

[12] UPR 9002 CNRS,undefined

[13] Institute of Molecular and Cellular Biology,undefined

[14] 15 rue R. Descartes,undefined

[15] 67084 Strasbourg,undefined

[16] France ,undefined

[17] Laboratory of Genetics,undefined

[18] University of Camerino,undefined

来源：

Nature | 2008年 / 455卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Proteins known as initiation factors (IFs) help to position the 30S subunit of the ribosome correctly on the mRNA start site so that the proper reading frame is engaged. After formation of this 30S initiation complex, the 50S ribosomal subunit binds and the IFs are released. In this work, Simonetti et al. use cryo-electron microscopy to examine the position of the mRNA, initiator tRNA, IF1 and IF2 in the 30S particle. From this structure, they predict how the 50S subunit interacts with the 30S initiation complex, and how GTP bound to IF2 is positioned towards the incoming GTPase-activated centre of the 50S.

引用

页码：416 / 420

页数：4

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