Three new azaphilones produced by a marine fish-derived chaetomium globosum

被引：0
|
作者：
Takeshi Yamada
Masaaki Jinno
Takashi Kikuchi
Tetsuya Kajimoto
Atsushi Numata
Reiko Tanaka
机构：
[1] Osaka University of Pharmaceutical Sciences,
[2] Laboratory of Medical Chemistry,undefined
来源：
The Journal of Antibiotics | 2012年 / 65卷
关键词：
azaphilones; Chaetomium sp; chaetomugilins; cytotoxicity; dechlorine derivative;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Three new metabolites, chaetomugilin S, dechloro-chaetomugilin A and dechloro-chaetomugilin D, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and some chemical transformations. Particularly, chaetomugilins T and U are the first compouds without a chlorine atom in azaphilones isolated from this fungal strain, to date. In addition, these compounds moderately inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.
引用
收藏
页码：413 / 417
页数：4
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