Effects of human T-lymphotropic virus type II on human immunodeficiency virus type 1 phenotypic evolution

被引：0
|
作者：
P. C. Guenthner
R. C. Hershow
R. B. Lal
C. S. Dezzutti
机构：
[1]  HIV and Retrovirology Branch,
[2] Division of AIDS,undefined
[3] STD,undefined
[4] and TB Laboratory Research,undefined
[5] Centers for Disease Control and Prevention,undefined
[6] Atlanta,undefined
[7] Georgia,undefined
[8] U.S.A.,undefined
[9]  University of Illinois at Chicago,undefined
[10] College of Medicine and School of Public Health,undefined
[11] Chicago,undefined
[12] Illinois,undefined
[13] U.S.A.,undefined
来源：
Archives of Virology | 2001年 / 146卷
关键词：
Human Immunodeficiency Virus; Human Immunodeficiency Virus Type; Virus Type; Phenotypic Change; Primary Isolate;
D O I：
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中图分类号：
学科分类号：
摘要：
 Phenotypic change and broader coreceptor usage by HIV-1 have been associated with disease progression. HIV-1 coreceptor usage by primary isolates obtained from HIV-1-infected and HIV-1/HTLV-II-coinfected individuals was determined. HIV-1 was isolated from 15 of 20 HIV-1-infected and 17 of 24 HIV-1/HTLV-II-coinfected individuals. None of the isolates from either the HIV-1-infected or the coinfected group infected CCR5Δ32 PBMCs, suggesting that they all were R5-tropic. Further, both spontaneous and PHA-stimulated production of MIP-1β and RANTES were similar in HIV-1-infected and coinfected individuals. These data indicate that coinfection with HTLV-II has no effect on HIV-1 coreceptor usage or ex vivo β-chemokine production.
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页码：1617 / 1622
页数：5
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