Testicular relapse of acute promyelocytic leukemia after allogeneic BMT

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作者
DL Forrest
BI Dalal
SC Naiman
DE Horsman
BR Berry
MI Parslow
CP Singh
WB Benny
MJ Barnett
机构
[1] British Columbia Cancer Agency,Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Hematology
[2] Vancouver Hospital and Health Sciences Centre and the University of British Columbia,Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Hematopathology
[3] British Columbia Cancer Agency,Leukemia/Bone Marrow Transplantation Program of British Columbia: Divisions of Laboratory Medicine
[4] Vancouver Hospital and Health Sciences Centre and the University of British Columbia,undefined
[5] British Columbia Cancer Agency,undefined
[6] Vancouver Hospital and Health Sciences Centre and the University of British Columbia,undefined
[7] Greater Victoria Hospital Society,undefined
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关键词
testicular relapse; acute promyelocytic leukemia; allogeneic BMT;
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摘要
After treatment of acute leukemia (typically ALL and the monocytic variants of AML), relapse may occur at sites other than the marrow. Isolated extramedullary relapse of acute promyelocytic leukemia (APL) however, is rare. We describe such an event in a man who underwent allogeneic BMT for APL in second relapse and 4 years later presented with testicular relapse. The marrow was morphologically and cytogenetically normal, but RT-PCR analysis revealed the specific PML/RAR chimeric RNA transcript.
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页码:689 / 690
页数:1
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