Analytical estimation of the power of linkage analysis in large pedigrees

被引：0
|
作者：
G. R. Svischeva
T. I. Axenovich
机构：
[1] Russian Academy of Sciences,Institute of Cytology and Genetics, Siberian Branch
来源：
Russian Journal of Genetics | 2010年 / 46卷
关键词：
Linkage Analysis; Analytical Estimation; Nuclear Family; Mathematical Expectation; Large Pedigree;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Different approaches to analytical calculation of the power in linkage analysis whose efficiencies have been demonstrated in small pedigrees are described. The possibility of applying them to large pedigrees has been estimated. Equivalence of the analytical estimates of power obtained using different approaches based on analysis of individual pairs of relatives has been shown. The accuracy of the resultant analytical estimation of the power has been analyzed for three large pedigrees and a wide range of quantitative trait inheritance models; the accuracy has been demonstrated to be sufficiently high and equal to the accuracy in the case of small pedigrees.
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页码：105 / 112
页数：7
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