TUSC3: functional duality of a cancer gene

被引:0
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作者
Kateřina Vašíčková
Peter Horak
Petr Vaňhara
机构
[1] Masaryk University,Department of Histology and Embryology, Faculty of Medicine
[2] St. Anne’s University Hospital Brno,International Clinical Research Center
[3] National Center for Tumor Diseases (NCT),Department of Translational Oncology
[4] German Cancer Research Center (DKFZ),undefined
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关键词
TUSC3; Cancer; Tumor suppressor; Oncogene; Endoplasmic reticulum; N-Glycosylation; Immunoediting;
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摘要
Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum.
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页码:849 / 857
页数:8
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