An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity

被引：0
|
作者：
Lian-sheng Cheng
Min Zhu
Yan Gao
Wen-ting Liu
Wu Yin
Pengfei Zhou
Zhongliang Zhu
Liwen Niu
Xiaoli Zeng
Dayan Zhang
Qing Fang
Fengrong Wang
Qun Zhao
Yan Zhang
Guodong Shen
机构：
[1] University of Science and Technology of China,Department of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Gerontology Institute of Anhui Province, Division of Life Sciences and Medicine
[2] Hefei HankeMab Biotechnology Limited,Anhui Province Key Laboratory of Gene Engineering Pharmaceutical, Biomedicine Technology Innovation Center of Hefei
[3] Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy,School of Life Sciences, Division of Life Sciences and Medicine
[4] Anhui Anke Biotechnology (Group) Co.,School of Health Service Management
[5] Ltd.,undefined
[6] University of Science and Technology of China,undefined
[7] Anhui Medical University,undefined
来源：
Cellular & Molecular Biology Letters | / 28卷
关键词：
Colorectal cancer; Cancer immunotherapy; 4-1BB/CD137; PD-1/PD-L1; Immune checkpoint inhibitor; Antitumor immunity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
    Cheng, Lian-sheng
    Zhu, Min
    Gao, Yan
    Liu, Wen-ting
    Yin, Wu
    Zhou, Pengfei
    Zhu, Zhongliang
    Niu, Liwen
    Zeng, Xiaoli
    Zhang, Dayan
    Fang, Qing
    Wang, Fengrong
    Zhao, Qun
    Zhang, Yan
    Shen, Guodong
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 2023, 28 (01)
  • [2] The bispecific antibody KA-3004, targeting PD-L1 and 4-1BB, is designed to enhance anti- tumor activity
    Liang, Jiabei
    Guo, Zhengcheng
    Peng, Hao
    Hao, Feng
    Liu, Tongtong
    Ning, Jinying
    Wu, Guojin
    CANCER RESEARCH, 2024, 84 (06)
  • [3] A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity
    Cheng, Lian-sheng
    Cheng, Yong-feng
    Liu, Wen-ting
    Shen, Aolin
    Zhang, Dayan
    Xu, Tingjuan
    Yin, Wu
    Cheng, Min
    Ma, Xiaopeng
    Wang, Fengrong
    Zhao, Qun
    Zeng, Xiaoli
    Zhang, Yan
    Shen, Guodong
    JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)
  • [4] A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity
    Lian-sheng Cheng
    Yong-feng Cheng
    Wen-ting Liu
    Aolin Shen
    Dayan Zhang
    Tingjuan Xu
    Wu Yin
    Min Cheng
    Xiaopeng Ma
    Fengrong Wang
    Qun Zhao
    Xiaoli Zeng
    Yan Zhang
    Guodong Shen
    Journal of Translational Medicine, 20
  • [5] The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling
    Tianye Li
    Mengke Niu
    Jianwei Zhou
    Kongming Wu
    Ming Yi
    Cell Communication and Signaling, 22
  • [6] The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling
    Li, Tianye
    Niu, Mengke
    Zhou, Jianwei
    Wu, Kongming
    Yi, Ming
    CELL COMMUNICATION AND SIGNALING, 2024, 22 (01)
  • [7] Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma
    Wang, Yichen
    Zhang, Xuyao
    Xu, Caili
    Nan, Yanyang
    Fan, Jiajun
    Zeng, Xian
    Kwon, Byoung S.
    Ju, Dianwen
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [8] Phase 1 trial safety and efficacy of ragistomig, a bispecific antibody targeting PD-L1 and 4-1BB, in advanced solid tumors
    Falchook, Gerald Steven
    LoRusso, Patricia
    Goldman, Jonathan W.
    El-Khoueiry, Anthony B.
    Tolcher, Anthony W.
    Xing, Yan
    Henry, Jason Timothy
    Keam, Bhumsuk
    Kim, Dong-Wan
    Kim, Tae-Yong
    Kim, Hye Ryun
    Hong, Min Hee
    Kim, Min Hwan
    Lee, Dae Ho
    Lee, SangMi
    Jeon, JuYeun
    Hayslip, John W.
    Xu, Cong
    Garon, Edward B.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [9] A humanized anti-MSLNx4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity
    Zhang, Da-yan
    Zhang, Zhi-hua
    Liu, Wen-ting
    Zhou, Wei-ming
    Zhou, Peng-fei
    Wei, Juan-juan
    Dai, Xue-jing
    Zeng, Xiao-li
    Zhou, Yu-qiong
    Li, Han-wang
    Zhang, Heng
    Shen, Ao-lin
    Cheng, Lian-sheng
    Shen, Guo-dong
    He, Yi-fu
    JOURNAL OF TRANSLATIONAL MEDICINE, 2025, 23 (01)
  • [10] GEN1046 (Bispecific Antibody Targeting PD-L1 and 4-1BB): Preclinical Characteristics and Phase 1 Results in Solid Tumors
    Kunkel, Maria
    Muik, Alexander
    Altintas, Isil
    Gieseke, Friederike
    Schodel, Kristina
    Diken, Mustafa
    Sette, Angelica
    Stanganello, Eliana
    Vascotto, Fulvia
    Breij, Esther
    Sasser, Kate
    Tureci, Ozlem
    Forssmann, Ulf
    Ahmadi, Tahamtan
    Sahin, Ugur
    CANCER SCIENCE, 2023, 114 : 1566 - 1566
12345