Premedication with Tramadol in Patients Undergoing Colonoscopy: A Double-Blind Randomized Placebo-Controlled Study

被引:0
|
作者
Laurino Grossi
Giorgio Cappello
Leonardo Marzio
机构
[1] School of Gastroenterology,Department of Medicine and Sciences of Aging
来源
关键词
tramadol; colonoscopy; premedication;
D O I
暂无
中图分类号
学科分类号
摘要
Colonoscopy is often disturbed by poor patient tolerance; benzodiazepines or opiates are routinely used to overcome such problems, despite the possibility of undesired effects. Tramadol, an opiate analogue with potentially fewer side effects, has not been tested yet to this end. The aim of the study was therefore to evaluate the efficacy of tramadol as a premedication for the colonoscopic procedure. Fifty patients were randomly allocated to receive an i.v. infusion of 100 ml saline, with 100 mg tramadol or alone, before endoscopy. At the end of the procedure patients were asked to score the discomfort experienced and to give an exam evaluation. The endoscopist also analyzed his performance. Tramadol patients reported a pain score of 39 ± 10 (mean ± SE), compared to 45 ± 8 for the placebo group (P=0.25); the evaluation of endoscopy was also similar (tramadol, 66 ± 12; placebo, 70 ± 9; P=0.15). The endoscopist also reported a similar score (65 ± 4 after tramadol; 69 ± 4 after placebo; P=0.2). No significant sex- or age-related differences were detected. We conclude that tramadol, at least as a monotherapy, seems scarcely effective for controlling pain evoked by colonoscopy.
引用
收藏
页码:1641 / 1645
页数:4
相关论文
共 50 条
  • [1] Premedication with tramadol in patients undergoing colonoscopy: A double-blind randomized placebo-controlled study
    Grossi, L
    Cappello, G
    Marzio, L
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2004, 49 (10) : 1641 - 1645
  • [2] Pregabalin as a premedication for anxiety in patients undergoing plastic surgery: randomized double-blind, placebo-controlled study
    Cortes-Martinez, Ludivina A.
    Cardoso-Garcia, Luis E.
    Galvan-Talamantes, Yazmin
    Morales-Maza, Jesus
    Rosas-Sanchez, Mario A.
    Vargas-Aguilar, Dulce M.
    Banuelos-Ortiz, Elise
    Alvarez-Resendiz, Gerardo E.
    [J]. CIRUGIA Y CIRUJANOS, 2020, 88 (05): : 548 - 553
  • [3] A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy
    Maltais, F
    Laberge, F
    Laviolette, M
    [J]. CHEST, 1996, 109 (05) : 1195 - 1198
  • [4] Clonidine premedication in patients with sleep apnea syndrome: A randomized, double-blind, placebo-controlled study
    Pawlik, MT
    Hansen, E
    Waldhauser, D
    Selig, C
    Kuehnel, TS
    [J]. ANESTHESIA AND ANALGESIA, 2005, 101 (05): : 1374 - 1380
  • [5] Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study
    Shavakhi, A.
    Ardestani, S. K.
    Taki, M.
    Goli, M.
    Keshteli, A. H.
    [J]. ACTA GASTRO-ENTEROLOGICA BELGICA, 2012, 75 (03) : 349 - 353
  • [6] Diphenhydramine as an adjunct to sedation for colonoscopy: a double-blind randomized, placebo-controlled study
    Tu, RH
    Grewall, P
    Leung, JW
    Suryaprasad, AG
    Sheykhzadeh, PI
    Doan, C
    Garcia, JC
    Zhang, N
    Prindiville, T
    Mann, S
    Trudeau, W
    [J]. GASTROINTESTINAL ENDOSCOPY, 2006, 63 (01) : 87 - 94
  • [7] PREMEDICATION FOR PTA - DOUBLE-BLIND AND RANDOMIZED COMPARISON OF MIDAZOLAM TRAMADOL VERSUS PLACEBO TRAMADOL
    ALFKE, H
    REUTER, P
    WAGNER, HJ
    BOHME, K
    [J]. FORTSCHRITTE AUF DEM GEBIETE DER RONTGENSTRAHLEN UND DER NEUEN BILDGEBENDEN VERFAHREN, 1993, 159 (05): : 461 - 466
  • [8] Use of Baclofen Premedication as an Analgesic Adjuvant in Patients Undergoing Percutaneous Nephrolithotripsy: A Placebo-Controlled, Double-Blind Randomized Trial
    Mandabach, Mark
    Deichmann, Page
    Massoll, Anthony
    Graves, Shanna
    Assimos, Dean
    Wood, Kyle
    Ness, Timothy J.
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
  • [9] Melatonin as premedication for laparoscopic cholecystectomy: a double-blind, placebo-controlled study
    Ionescu, D.
    Badescu, C.
    Ilie, A.
    Miclutia, I
    Iancu, C.
    Ion, D.
    Vasian, H.
    Acalovschi, I
    Mocan, T.
    Bondor, C.
    [J]. SOUTHERN AFRICAN JOURNAL OF ANAESTHESIA AND ANALGESIA, 2008, 14 (04) : 8 - 11
  • [10] Continuous infusion of lidocaine in pediatric colonoscopy: A randomized double-blind placebo-controlled study
    Yuan, Chao
    Wang, Chengli
    Wu, Jiayao
    Gao, Ningyang
    Li, Kunwei
    Li, Yongle
    Huang, Xizhao
    Huang, Wei
    Hu, Zurong
    [J]. SAUDI JOURNAL OF GASTROENTEROLOGY, 2022, 28 (01): : 54 - 59