Immune and inflammatory response in pigs during acute influenza caused by H1N1 swine influenza virus

被引:0
|
作者
Małgorzata Pomorska-Mól
Iwona Markowska-Daniel
Krzysztof Kwit
Ewelina Czyżewska
Arkadiusz Dors
Jarosław Rachubik
Zygmunt Pejsak
机构
[1] National Veterinary Research Institute,Department of Swine Diseases
[2] National Veterinary Research Institute,Department of Radiobiology
来源
Archives of Virology | 2014年 / 159卷
关键词
Influenza; Lung Lesion; Caudal Lobe; Swine Influenza; Nasal Swab;
D O I
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中图分类号
学科分类号
摘要
Swine influenza (SI) is an acute respiratory disease of pigs, caused by swine influenza virus (SIV). Little is known about the inflammatory response in the lung during acute SI and its correlation with clinical signs or lung pathology. Moreover, until now there has been a limited amount of data available on the relationship between the concentrations of pro- and anti-inflammatory cytokines in the lungs and the serum concentration of acute-phase proteins (APPs) in SIV-infected pigs. In the present study, the porcine inflammatory and immune responses during acute influenza caused by H1N1 SIV (SwH1N1) were studied. Nine pigs were infected intratracheally, and five served as controls. Antibodies against SIV were measured by haemagglutination inhibition assay, and the influenza-virus-specific T-cell response was measured using a proliferation assay. C-reactive protein (CRP), haptoglobin (Hp), serum amyloid A (SAA), and pig major acute-phase protein (Pig-MAP) the concentrations in serum and concentration of IL-1β, IL-6, IL-8, IL-10, TNF-α and IFN-γ in lung tissues were measured using commercial ELISAs.
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页码:2605 / 2614
页数:9
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