One pot synthesis of cinchona functionalized mesoporous silica and its enantioselectivity

Cinchona functionalized mesoporous silica is synthesized by one pot synthesis method. The main silica precursor (TEOS) is co-condensed with a cinchonidine molecule linked organosilane which is renovated by triethoxy silane moiety at its C11 position to yield cinchona functionalized silica. The subsequent deposition of Pt nanoparticles over functionalized silica provides a catalytic system for the enantioselective hydrogenation of α-activated ketone (Orito’s reaction). Thus-developed catalyst system is found to be enantioselective with an enantiomeric excess (e.e) of 35.6%.