Biological evaluation of novel gemcitabine analog in patient-derived xenograft models of pancreatic cancer

被引：0

作者：

Andriana Inkoom

Nkafu Bechem Ndemazie

Taylor Smith

Esther Frimpong

Raviteja Bulusu

Rosemary Poku

Xue Zhu

Bo Han

Jose Trevino

Edward Agyare

机构：

[1] Florida A&M University,College of Pharmacy and Pharmaceutical Sciences

[2] Central Michigan University,College of Medicine

[3] Keck School of Medicine University of Southern California,Department of Surgery

[4] University of Florida College of Medicine,Department of Surgery

[5] Virginia Commonwealth University,Department of Surgery, College of Medicine

来源：

BMC Cancer | / 23卷

关键词：

Black; White; 4-N-stearoyl Gemcitabine; Solid-lipid nanoparticle; Pancreatic cancer; Antitumor efficacy; Patient-derived xenograft model;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability (short half-life) limit its clinical outcome. The objective of this study was to modify Gem into a more stable form called 4-(N)-stearoyl-gemcitabine (4NSG) and evaluate its therapeutic efficacy in patient-derived xenograft (PDX) models from PCa of Black and White patients.

引用

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Poku, Rosemary
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[J]. BMC CANCER, 2023, 23 (01)
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