Novel Strategy for Treatment of Pulmonary Arterial Hypertension: Enhancement of Apoptosis

被引：0
|
作者：
Jing-bin Huang
Ying-long Liu
Pei-wu Sun
Xiao-dong Lv
Kong Bo
Xiang-ming Fan
机构：
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,Pediatric Center of Cardiac Surgery, Cardiovascular Institute and Fuwai Hospital
[2] First Affiliated Hospital of Sun Yat-Sen University,Department of Cardiovascular and Thoracic Surgery
来源：
Lung | 2010年 / 188卷
关键词：
Pulmonary vascular remodeling; PASMC; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Advanced pulmonary arterial hypertension is characterized by extensive vascular remodeling that is usually resistant to vasodilator therapy. As the major component of the vascular media, decreased apoptosis of pulmonary arterial smooth muscle cell (PASMC) plays key roles during pulmonary vascular remodeling. Recent studies showed that enhancement of apoptosis of PASMC can reverse pulmonary vascular remodeling and severe pulmonary arterial hypertension. Enhancement of apoptosis of PASMC is becoming a novel strategy to reverse severe pulmonary arterial hypertension. This review analyzes some potential strategies to reverse pulmonary vascular remodeling.
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页码：179 / 189
页数：10
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