Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion

被引：0
|
作者：
Mohammed Maniruzzaman
Muhammad T. Islam
Sheelagh Halsey
Devyani Amin
Dennis Douroumis
机构：
[1] University of Greenwich,School of Sciences, Faculty of Engineering and Science
[2] Thermo Fisher Scientific,undefined
来源：
AAPS PharmSciTech | 2016年 / 17卷
关键词：
controlled release; hot melt extrusion; in-line NIR; solid dispersions;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides—Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5.
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页码：191 / 199
页数：8
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