Propagation of conformational changes during μ-opioid receptor activation

被引：0
|
作者：
Rémy Sounier
Camille Mas
Jan Steyaert
Toon Laeremans
Aashish Manglik
Weijiao Huang
Brian K. Kobilka
Héléne Déméné
Sébastien Granier
机构：
[1] Institut de Genomique Fonctionnelle,Department of Molecular and Cellular Physiology
[2] CNRS UMR-5203 INSERM U1191,undefined
[3] University of Montpellier,undefined
[4] Structural Biology Brussels,undefined
[5] Vrije Universiteit Brussel,undefined
[6] Structural Biology Research Center,undefined
[7] VIB,undefined
[8] Stanford University School of Medicine,undefined
[9] Centre de Biochimie Structurale,undefined
[10] CNRS UMR 5048-INSERM 1054- University of Montpellier,undefined
来源：
Nature | 2015年 / 524卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
NMR spectroscopy reveals the conformational changes of the μ-opioid receptor that are associated with receptor activation, helping to explain why the allosteric coupling between the agonist-binding pocket and the cytoplasmic G-protein-coupling interface of this receptor is relatively weak.
引用
收藏
页码：375 / 378
页数：3
相关论文
共 50 条
  • [1] Propagation of conformational changes during μ-opioid receptor activation
    Sounier, Remy
    Mas, Camille
    Steyaert, Jan
    Laeremans, Toon
    Manglik, Aashish
    Huang, Weijiao
    Kobilka, Brian K.
    Demene, Helene
    Granier, Sebastien
    NATURE, 2015, 524 (7565) : 375 - +
  • [2] β-arrestin2 conformational changes are induced by μ-opioid receptor activation
    Underwood, Owen
    Haider, Raphael
    Lane, J. Robert
    Briddon, Stephen
    Hoffmann, Carsten
    Canals, Meritxell
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 (04) : 484 - 485
  • [3] Pharmacological Characterization of μ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation
    Piekielna-Ciesielska, Justyna
    Artali, Roberto
    Azzam, Ammar A. H.
    Lambert, David G.
    Kluczyk, Alicja
    Gentilucci, Luca
    Janecka, Anna
    MOLECULES, 2021, 26 (01):
  • [4] CONFORMATIONAL-CHANGES OF OPIOID RECEPTOR INDUCED BY THE ELECTRIC FOOTSHOCK
    NABESHIMA, T
    MATSUNO, K
    KAMEYAMA, T
    BRAIN RESEARCH, 1985, 343 (01) : 36 - 43
  • [5] Activation of the μ opioid receptor involves conformational rearrangements of multiple transmembrane domains
    Xu, Wei
    Sanz, Arantxa
    Pardo, Leonardo
    Liu-Chen, Lee-Yuan
    BIOCHEMISTRY, 2008, 47 (40) : 10576 - 10586
  • [6] Conformational rearrangement during activation of a metabotropic glutamate receptor
    Liauw, Brandon Wey-Hung
    Afsari, Hamid Samareh
    Vafabakhsh, Reza
    NATURE CHEMICAL BIOLOGY, 2021, 17 (03) : 291 - +
  • [7] Conformational Rearrangement During Activation of a Metabotropic Glutamate Receptor
    Liauw, Brandon W.
    Afsari, Hamid S.
    Vafabakhsh, Reza
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 124A - 124A
  • [8] Conformational rearrangement during activation of a metabotropic glutamate receptor
    Brandon Wey-Hung Liauw
    Hamid Samareh Afsari
    Reza Vafabakhsh
    Nature Chemical Biology, 2021, 17 : 291 - 297
  • [9] Conformational changes in the parathyroid hormone receptor associated with activation by agonist
    Thomas, Beena E.
    Woznica, Iwona
    Mierke, Dale F.
    Wittelsberger, Angela
    Rosenblatt, Michael
    MOLECULAR ENDOCRINOLOGY, 2008, 22 (05) : 1154 - 1162
  • [10] Conformational changes in the activation loop of the insulin receptor's kinase domain
    Frankel, M
    Bishop, SM
    Ablooglu, AJ
    Han, YP
    Kohanski, RA
    PROTEIN SCIENCE, 1999, 8 (10) : 2158 - 2165
12345