ASPP1 and ASPP2 are new transcriptional targets of E2F

被引：0
|
作者：
V Fogal
N N Kartasheva
G Trigiante
S Llanos
D Yap
K H Vousden
X Lu
机构：
[1] University College London,Ludwig Institute for Cancer Research
[2] Garscube Estate,Beatson Institute for Cancer Research
来源：
Cell Death & Differentiation | 2005年 / 12卷
关键词：
E2F; ASPP; promoter; transcriptional activation; apoptosis; cancer; p53;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The E2F family of transcription factors regulates the expression of a number of genes whose products are involved in cell cycle control, DNA replication and apoptosis. We show here that E2F-1 binds in vivo the promoters of ASPP1 and ASPP2 genes, two activators of p53-mediated apoptosis, E2F-1, E2F-2 and E2F-3 all activate the isolated ASPP1 and ASPP2 promoters. Overexpression or deregulation of E2F-1 increased the expression levels of ASPP1 and ASPP2 mRNA and proteins. The identification of ASPP1 and ASPP2 genes as transcriptional targets of E2F provides another mechanism by which E2F cooperates with p53 to induce apoptosis.
引用
收藏
页码：369 / 376
页数：7
相关论文
共 50 条
  • [1] ASPP1 and ASPP2 are new transcriptional targets of E2F
    Fogal, V
    Kartasheva, NN
    Trigiante, G
    Llanos, S
    Yap, D
    Vousden, KH
    Lu, X
    [J]. CELL DEATH AND DIFFERENTIATION, 2005, 12 (04): : 369 - 376
  • [2] ASPP1 and ASPP2: Common activators of p53 family members
    Bergamaschi, D
    Samuels, Y
    Jin, BQ
    Duraisingham, S
    Crook, T
    Lu, X
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (03) : 1341 - 1350
  • [3] The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly
    Zhang, Yuanyuan
    Wang, Yuqi
    Wei, Youheng
    Ma, Jian
    Peng, Jingtao
    Wumaier, Reziya
    Shen, Suqin
    Zhang, Pingzhao
    Yu, Long
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (03) : 494 - 500
  • [4] Epigenetic silence of ASPP1 and ASPP2 genes promotes tumor growth in HBV-positive hepatocellular carcinoma
    Zhao, Jian
    Guo, Yajun
    [J]. CANCER RESEARCH, 2010, 70
  • [5] ΔN-ASPP2 is a novel isoform of the ASPP2 tumor suppressor and a regulator of ASPP2 function
    Van Hook, Kathryn
    Wang, Zhiping
    Chen, Dexi
    Lee, Hun Joo
    Zhu, Zhiyi
    Lopez, Charles
    [J]. CANCER RESEARCH, 2011, 71
  • [6] Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax
    Patel, Seema
    George, Roger
    Autore, Flavia
    Fraternali, Franca
    Ladbury, John E.
    Nikolova, Penka V.
    [J]. NUCLEIC ACIDS RESEARCH, 2008, 36 (16) : 5139 - 5151
  • [7] The expression of ASPP2 and its new isoform delta-ASPP2 in HCC
    Shi, Ying
    Liu, Kai
    Ding, Huiguo
    Lv, Fudong
    Lopez, Charles
    Li, Ning
    Chen, Dexi
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [8] ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
    Wang, Y.
    Godin-Heymann, N.
    Wang, X. Dan
    Bergamaschi, D.
    Llanos, S.
    Lu, X.
    [J]. CELL DEATH AND DIFFERENTIATION, 2013, 20 (04): : 525 - 534
  • [9] 非小细胞肺癌中ASPP1、ASPP2蛋白的不同表达状态及其意义
    苏胜发
    卢冰
    苏敏
    李大中
    何常
    钟愉
    [J]. 肿瘤预防与治疗, 2008, (02) : 123 - 126
  • [10] ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
    Y Wang
    N Godin-Heymann
    X Dan Wang
    D Bergamaschi
    S Llanos
    X Lu
    [J]. Cell Death & Differentiation, 2013, 20 : 525 - 534
12345