Osteoblasts in prostate cancer metastasis to bone

被引：0
|
作者：
Christopher J. Logothetis
Sue-Hwa Lin
机构：
[1] University of Texas,Department of Genitourinary Oncology
[2] M.D. Anderson Cancer Center,Department of Molecular Pathology
[3] University of Texas,undefined
[4] M.D. Anderson Cancer Center,undefined
来源：
Nature Reviews Cancer | 2005年 / 5卷
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摘要：
Patients with advanced prostate cancer frequently develop bone metastases.The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of interactions between prostate cancer cells and osteoblasts. Prostate cancer cells might depend on an osteoblast-derived factor for their growth.Prostate cancer cells produce factors that perturb the bone microenvironment in ways that affect the normal functional balance between osteoblast and osteoclast activities, resulting in osteoblastic metastases.Osteoblasts also secrete factors that facilitate progression of prostate cancer in bone.Therapeutics designed to target the interaction between prostate cancer and osteoblasts might prevent or treat prostate cancer bone metastases.
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页码：21 / 28
页数：7
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