The role of statins as potential targets for bone formation

被引：0
|
作者：
I Ross Garrett
Greg R Mundy
机构：
[1] OsteoScreen,
[2] The Institute of Drug Development,undefined
来源：
Arthritis Research & Therapy | / 4卷
关键词：
bone formation; HMG-CoA reductase inhibitors; osteoblasts; osteoporosis; statins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors increase the gene expression of bone morphogenetic protein-2, which is an autocrine-paracrine factor for osteoblast differentiation.
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