Effects of NAD-299, a new, highly selective 5-HT1A receptor antagonist, on bladder function in rats

被引：0
|
作者：
Rikard Pehrson
Göran Öjteg
Osamu Ishizuka
Karl-Erik Andersson
机构：
[1] Department of Clinical Pharmacology,
[2] Lund University Hospital,undefined
[3] 221 85 Lund,undefined
[4] Sweden,undefined
[5] AstraZeneca R and D Södertälje,undefined
[6] 151 85 Södertälje,undefined
[7] Sweden,undefined
[8] Department of Urology,undefined
[9] Shinshu University School of Medicine,undefined
[10] Asahi 3-1-1,undefined
[11] Matsumoto 390–8621,undefined
[12] Japan,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2002年 / 366卷
关键词：
Micturition Serotonin 5-HT1A Raphe nuclei Antagonism NAD-299 WAY100635;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
5-HT is involved in micturition control. In the rat, stimulation of the 5-HT1A receptor excites, whereas 5-HT1A receptor antagonism inhibits micturition. The present study examined the effects of a new, highly selective, 5-HT1A receptor antagonist, NAD-299, on micturition in rats. Comparisons were made with WAY100635, a well-characterised antagonist at the 5-HT1A receptor.
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页码：528 / 536
页数：8
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