Trophic Effects of Nootropic Peptide Preparations Cerebrolysin and Semax on Cultured Rat Pheochromocytoma

被引：0
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作者：
E. R. Safarova
S. I. Shram
I. A. Grivennikov
N. F. Myasoedov
机构：
[1] Russian Academy of Sciences,Institute of Molecular Genetics
来源：
Bulletin of Experimental Biology and Medicine | 2002年 / 133卷
关键词：
neuroprotection; trophic factors; cerebrolysin; semax; PC12 rat pheochromocytoma cell culture;
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摘要：
Trophic characteristics of neuroprotectors cerebrolysin and semax were evaluated by their capacity to induce differentiation and improve survival of cultured rat pheochromocytoma (PC12) cells. Morphological signs of cell differentiation (enlargement and formation of processes) were seen 24 h after addition of cerebrolysin into culture medium. Cerebrolysin improved survival of PC12 cells in serum-free medium. In a concentration of 100 mug/ml cerebrolysin decreased the content of apoptotic cells from 32% (control) to 10%. Semax produced no trophic effect on PC12 cells. hence, the neuroprotective effect of cerebrolysin in vivo probably results from trophic activity, while the protective effects of semax are mediated by other mechanisms.
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页码：401 / 403
页数：2
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