Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

被引:0
|
作者
E E Vincent
D J E Elder
E C Thomas
L Phillips
C Morgan
J Pawade
M Sohail
M T May
M R Hetzel
J M Tavaré
机构
[1] School of Biochemistry,Department of Respiratory Medicine
[2] Medical Sciences Building,Division of Histopathology
[3] University of Bristol,undefined
[4] Bristol Royal Infirmary,undefined
[5] Bristol BS2 8HW,undefined
[6] UK,undefined
[7] Bristol Royal Infirmary,undefined
[8] School of Social and Community Medicine,undefined
[9] Canynge Hall,undefined
[10] University of Bristol,undefined
来源
British Journal of Cancer | 2011年 / 104卷
关键词
protein kinase B; Akt; biomarker; tumour; phosphorylation;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1755 / 1761
页数:6
相关论文
共 50 条
  • [1] Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer
    Vincent, E. E.
    Elder, D. J. E.
    Thomas, E. C.
    Phillips, L.
    Morgan, C.
    Pawade, J.
    Sohail, M.
    May, M. T.
    Hetzel, M. R.
    Tavare, J. M.
    [J]. BRITISH JOURNAL OF CANCER, 2011, 104 (11) : 1755 - 1761
  • [2] AKT phosphorylation sites of Ser473 and Thr308 regulate AKT degradation
    Wei, Yingze
    Zhou, Jianyun
    Yu, Haiyan
    Jin, Xiaoxia
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2019, 83 (03) : 429 - 435
  • [3] Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase
    Su, Chih-Hao
    Wang, Cheng-Yi
    Lan, Keng-Hsin
    Li, Chung-Pin
    Chao, Yee
    Lin, Han-Chieh
    Lee, Shou-Dong
    Lee, Wei-Ping
    [J]. CELLULAR SIGNALLING, 2011, 23 (11) : 1824 - 1830
  • [4] Differential Akt phosphorylation at Ser473 and Thr308 in cultured neurons after exposure to glutamate in rats
    Kitagawa, K
    Takasawa, K
    Kuwabara, K
    Sasaki, T
    Tanaka, S
    Mabuchi, T
    Sugiura, S
    Omura-Matsuoka, E
    Matsumoto, M
    Hori, M
    [J]. NEUROSCIENCE LETTERS, 2002, 333 (03) : 187 - 190
  • [5] LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473
    Zhang, Yuanjiao
    Qian, Jiacheng
    Jiang, Mingmei
    Yang, Shu
    Zhou, Lianxin
    Zhang, Qin
    Lin, Liping
    Yang, Ye
    [J]. FRONTIERS IN ONCOLOGY, 2023, 13
  • [6] Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma
    Ouyang, YB
    Zhang, XH
    He, QP
    Wang, GX
    Siesjö, BK
    Hu, BR
    [J]. BRAIN RESEARCH, 2000, 876 (1-2) : 191 - 195
  • [7] Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner
    Yung, Hong Wa
    Charnock-Jones, D. Stephen
    Burton, Graham J.
    [J]. PLOS ONE, 2011, 6 (03):
  • [8] Intramolecular Inhibition of Ser473 Phosphorylation by Up-regulated Thr308 Phosphorylation in Akt Contributes to Enlargement of Infarct Size by Chronic Renal Failure
    Tobisawa, Toshiyuki
    Yano, Toshiyuki
    Miki, Takayuki
    Tanno, Masaya
    Kuno, Atushi
    Kouzu, Hidemichi
    Ogasawara, Makoto
    Muratsubaki, Shingo
    Ohno, Kohei
    Nishizawa, Keitaro
    Mizuno, Masashi
    Ohwada, Wataru
    Ishikawa, Satoko
    Miura, Tetsuji
    [J]. CIRCULATION, 2015, 132
  • [9] Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Cα in endothelial cells
    Partovian, C
    Simons, M
    [J]. CELLULAR SIGNALLING, 2004, 16 (08) : 951 - 957
  • [10] Dysregulation of two phosphorylation sites in Akt, Thr308 and Ser473, upon reperfusion mediates enlargement of myocardial infarct size by chronic renal failure
    Tobisawa, T.
    Yano, T.
    Miki, T.
    Kuno, A.
    Tanno, M.
    Kouzu, H.
    Ogasawara, M.
    Muratsubaki, S.
    Ohno, K.
    Miura, T.
    [J]. EUROPEAN HEART JOURNAL, 2015, 36 : 170 - 170