Targeting epitopes in prostate-specific membrane antigen for antibody therapy of prostate cancer

被引：0
|
作者：
Y Kinoshita
K Kuratsukuri
N Newman
P M Rovito
P T P Kaumaya
C Y Wang
G P Haas
机构：
[1] SUNY Upstate Medical University,Department of Urology
[2] SUNY Upstate Medical University,Department of Medicine
[3] Ohio State University,Department of Obstetrics and Gynecology
[4] VA Medical Center,undefined
来源：
Prostate Cancer and Prostatic Diseases | 2005年 / 8卷
关键词：
antibody; prostate-specific membrane antigen; LNCaP; prostate cancer; antitumor activity; glutamate carboxypeptidase II;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prostate-specific membrane antigen (PSMA) is a target for immunotherapy of prostate cancer. It has been shown that antibodies against PSMA inhibited the in vivo growth of LNCaP tumor. In the present study, monoclonal antibodies against four epitopes in PSMA were raised. MAb 24.4E6 (IgG1), specific for the epitope (residues 638–657) in PSMA, significantly reduced the growth rate of established LNCaP tumor in SCID mice. Mouse IgG was detected in the tumor of mice treated with 24.4E6, but not with an unrelated MAb. These results suggest that this epitope may be the main target in PSMA for antibody therapy of prostate cancer.
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页码：359 / 363
页数：4
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