Fractionated stereotactic radiosurgery for recurrent ependymoma in children

被引：0
|
作者：
Lindsey M. Hoffman
S. Reed Plimpton
Nicholas K. Foreman
Nicholas V. Stence
Todd C. Hankinson
Michael H. Handler
Molly S. Hemenway
Rajeev Vibhakar
Arthur K. Liu
机构：
[1] University of Colorado Denver,Department of Pediatrics
[2] University of Colorado Denver,Department of Radiation Oncology
[3] University of Colorado Denver,Department of Radiology
[4] University of Colorado Denver,Department of Neurosurgery
[5] Children’s Hospital Colorado,undefined
来源：
Journal of Neuro-Oncology | 2014年 / 116卷
关键词：
Ependymoma; Stereotactic radiosurgery; Pediatric; Recurrent;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Outcomes for children with relapsed ependymoma are poor. Re-irradiation is a potentially viable salvage option in these patients. Data were reviewed for 12 patients (median age 5.6 years) with relapsed ependymoma who received fractionated stereotactic radiosurgery (fSRS) following maximal surgical resection from 1995 to 2012. Four patients experienced a second recurrence, including 2 in-field and 2 distant failures. Median time to second recurrence (32 months) was significantly longer than time to first recurrence (24 months) (p = 0.008). Three-year local control was 89 %, and median event free survival from fSRS was 3.4 years. Radiation necrosis was observed in 6 patients, 3 who were symptomatic. In conclusion, fSRS offers durable response with a tolerable toxicity profile in children with recurrent EPN.
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页码：107 / 111
页数：4
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