EPAC Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part II. The role of EPAC Proteins in the Physiology and Pathology of the Heart

被引：0

作者：

Kryzhanovskii S.A. ^{[1
]}

Nikiforova T.D. ^{[1
]}

Vititnova M.B. ^{[1
]}

Durnev A.D. ^{[1
]}

机构：

[1] Zakusov Institute of Pharmacology, Moscow

来源：

Human Physiology | 2020年 / 46卷 / 4期

关键词：

acute ischemia; apoptosis; cardiac arrhythmias; cardiomyocytes; Epac1; proteins; Epac2; fibrosis; hypertrophy; inotropic and rhythmic activity; intracellular signaling pathways; remodeling;

D O I：

10.1134/S0362119720040076

中图分类号：

学科分类号：

摘要：

Abstract: The second part of the review presents modern ideas about vision of the role of Epac proteins in the regulation of inotropic and rhythmic functions of the heart, intercellular coupling of cardiomyocytes and their apoptosis. The contribution of Epac proteins to the development of hypertrophy, fibrosis, and myocardial remodeling, as well as their role in the genesis of acute ischemic damage to the heart muscle and cardiac arrhythmias, is examined in detail. © 2020, Pleiades Publishing, Inc.

引用

页码：443 / 464

页数：21

共 4 条

[1] Epac Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part 1: The Role of Epac Proteins in the Physiological and Pathological Processes of the Vasculature
Kryzhanovsky S.A.
Nikiforova T.D.
Durnev A.D.
[J]. Human Physiology, 2020, 46 (2) : 200 - 215
[2] Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease
Lezoualc'h, Frank
Fazal, Loubina
Laudette, Marion
Conte, Caroline
[J]. CIRCULATION RESEARCH, 2016, 118 (05) : 881 - 897
[3] New insights into arginase. Part II. Role in physiology and pathology
Mielczarek-Puta, Magdalena
Chrzanowska, Alicja
Grabon, Wojciech
Baranczyk-Kuzma, Anna
[J]. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2008, 62 : 214 - 221
[4] THE ROLE OF INSULIN-LIKE GROWTH-FACTORS AND IGF-BINDING PROTEINS IN THE PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES OF THE KIDNEY
ZUMKELLER, W
SCHOFIELD, PN
[J]. VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1992, 62 (04) : 207 - 220

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