Primary hyperhidrosis Evidence for autosomal dominant inheritance

被引：0
|
作者：
Horacio Kaufmann
Daniela Saadia
Charlene Polin
Stephen Hague
Amanda Singleton
Andrew Singleton
机构：
[1] Dept. of Neurology,
[2] Mount Sinai School of Medicine,undefined
[3] New York,undefined
[4] USA,undefined
[5] Dept. of Genetics,undefined
[6] Mount Sinai School of Medicine,undefined
[7] New York,undefined
[8] USA,undefined
[9] Laboratory of Neurogenetics,undefined
[10] National Institute on Aging,undefined
[11] National Institute of Health,undefined
[12] Bethesda,undefined
[13] USA,undefined
[14] Mount Sinai School of Medicine,undefined
[15] Box 1052,undefined
[16] New York,undefined
[17] NY 10029,undefined
[18] USA. horacio.kaufmann@mssm.edu,undefined
来源：
Clinical Autonomic Research | 2003年 / 13卷
关键词：
Key words: hyperhidrosis; genetic; inheritance; autosomal dominant;
D O I：
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学科分类号：
摘要：
Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of λs = 29–48 and an offspring recurrence risk of λo = 41–68 indicating that hyperhidrosis can be an inherited condition. The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance.
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页码：96 / 98
页数：2
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