The human cap-binding complex is functionally connected to the nuclear RNA exosome

被引：0

作者：

Peter Refsing Andersen

Michal Domanski

Maiken S Kristiansen

Helena Storvall

Evgenia Ntini

Celine Verheggen

Aleks Schein

Jakob Bunkenborg

Ina Poser

Marie Hallais

Rickard Sandberg

Anthony Hyman

John LaCava

Michael P Rout

Jens S Andersen

Edouard Bertrand

Torben Heick Jensen

机构：

[1] Centre for mRNP Biogenesis and Metabolism,Department of Molecular Biology and Genetics

[2] Aarhus University,Department of Cell and Molecular Biology

[3] Laboratory of Cellular and Structural Biology,Department of Biochemistry and Molecular Biology

[4] Rockefeller University,undefined

[5] Karolinska Institutet,undefined

[6] Institute de Génétique Moléculaire Montpellier,undefined

[7] CNRS,undefined

[8] University of Southern Denmark,undefined

[9] Max Planck Institute of Molecular Biology & Genetics,undefined

[10] Present addresses: Sir William Dunn School of Pathology,undefined

[11] University of Oxford,undefined

[12] Oxford,undefined

[13] UK (M.S.K.),undefined

[14] and Division of Genomic Technologies,undefined

[15] RIKEN,undefined

[16] Yokohama City,undefined

[17] Japan (A.S.).,undefined

来源：

Nature Structural & Molecular Biology | 2013年 / 20卷

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学科分类号：

摘要：

How the nuclear exosome is targeted to nuclear RNA substrates is poorly understood. An affinity-capture MS approach and functional analyses now demonstrate a physical and functional connection between the human exosome and the cap-binding complex (CBC). A CBC-containing complex was found to promote transcription termination of several RNA types, thus suggesting a direct link to exosomal RNA degradation.

引用

页码：1367 / 1376

页数：9

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