VHL, the story of a tumour suppressor gene

被引：0
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作者：
Lucy Gossage
Tim Eisen
Eamonn R. Maher
机构：
[1] Cambridge University Hospitals NHS Foundation Trust,Department of Oncology
[2] University of Cambridge,Department of Medical Genetics
[3] Cancer Research UK Cambridge Institute,undefined
[4] University of Cambridge,undefined
[5] University of Cambridge and NIHR Cambridge Biomedical Research Centre,undefined
来源：
Nature Reviews Cancer | 2015年 / 15卷
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摘要：
The identification in 1993 of inherited mutations in the von Hippel–Lindau (VHL) gene in families with VHL disease was a seminal finding. This and subsequent discoveries have given the VHLtumour suppressor gene a central role in our understanding of the mechanisms of cellular oxygen sensing and in the pathobiology of clear-cell renal cell carcinoma.
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页码：55 / 64
页数：9
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