New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L.

被引：0
|
作者：
Yuji Narukawa
Akiko Niimura
Hitomi Noguchi
Hiroomi Tamura
Fumiyuki Kiuchi
机构：
[1] Keio University,Faculty of Pharmacy
来源：
Journal of Natural Medicines | 2014年 / 68卷
关键词：
Labdane type diterpenoids; Estrogen sulfotransferase; Inhibitor;
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学科分类号：
摘要：
Four new diterpenoids (1–4), along with eight known diterpenoids (5–12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.). The structures of the compounds were determined by spectroscopic methods. Among the isolated compounds, compounds 2, 3, 8, 9 and 10 showed inhibitory activity against human liver cytosol estrogen sulfotransferase (E-ST), which plays a key role in the maintenance of cellular estrogen levels. Compound 2 showed the strongest activity with an IC50 value of 7.9 μM, which is comparable to the activity of the positive control, meclofenamic acid (IC50 5.4 μM).
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页码：125 / 131
页数：6
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