Strategies to incorporate translational research science into clinical trials in breast cancer

被引：0
|
作者：
Fumagalli D. [1 ]
Desmedt C. [1 ]
Piccart M. [1 ]
Sotiriou C. [1 ]
机构：
[1] Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Bruxelles 1000
来源：
Current Breast Cancer Reports | 2010年 / 2卷 / 4期
关键词：
Biomarkers of efficacy; Breast cancer; Breast international group; Clinical trials; Drug development; New target identification; Patient selection; Predictive signatures; Prognostic signatures; Translational research;
D O I：
10.1007/s12609-010-0028-y
中图分类号：
学科分类号：
摘要：
The advent of molecular oncology, accompanied by a whole new range of high-throughput experimental methods and their related technologies, has revealed that breast cancer is a complex disease and has led researchers to realize that the current approach to its treatment needs to be restructured. With clinical trials being the medium through which new knowledge generated by basic research can be applied to the management of cancer patients, efforts must be made to integrate translational research into clinical trial design and conduct. This article reports on different ways translational research can contribute to improving the structure and effectiveness of clinical trials, with the main aim to rapidly optimize and individualize the treatment of breast cancer patients. © 2010 Springer Science+Business Media, LLC.
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页码：208 / 213
页数：5
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