Targeted neurotechnology restores walking in humans with spinal cord injury

被引:0
|
作者
Fabien B. Wagner
Jean-Baptiste Mignardot
Camille G. Le Goff-Mignardot
Robin Demesmaeker
Salif Komi
Marco Capogrosso
Andreas Rowald
Ismael Seáñez
Miroslav Caban
Elvira Pirondini
Molywan Vat
Laura A. McCracken
Roman Heimgartner
Isabelle Fodor
Anne Watrin
Perrine Seguin
Edoardo Paoles
Katrien Van Den Keybus
Grégoire Eberle
Brigitte Schurch
Etienne Pralong
Fabio Becce
John Prior
Nicholas Buse
Rik Buschman
Esra Neufeld
Niels Kuster
Stefano Carda
Joachim von Zitzewitz
Vincent Delattre
Tim Denison
Hendrik Lambert
Karen Minassian
Jocelyne Bloch
Grégoire Courtine
机构
[1] Swiss Federal Institute of Technology (EPFL),Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences
[2] Lausanne University Hospital (CHUV),Department of Clinical Neuroscience
[3] University of Fribourg,Platform of Translational Neuroscience, Department of Neuroscience and Movement Science
[4] GTXmedical,Institute of Bioengineering
[5] Swiss Federal Institute of Technology (EPFL),Department of Radiology and Medical Informatics
[6] University of Geneva,Department of Neurosurgery
[7] Lausanne University Hospital (CHUV),Department of Diagnostic and Interventional Radiology
[8] Lausanne University Hospital (CHUV),Department of Nuclear Medicine and Molecular Imaging
[9] Lausanne University Hospital (CHUV),Department for Information Technology and Electrical Engineering
[10] Medtronic,Department of Engineering Science
[11] Foundation for Research on Information Technologies in Society (IT’IS),Faculty of Biology and Medicine
[12] Swiss Federal Institute of Technology (ETHZ),undefined
[13] University of Oxford,undefined
[14] University of Lausanne (UNIL),undefined
来源
Nature | 2018年 / 563卷
关键词
Overground Walking; Spatial Selectivity; Severe Locomotor Deficits; Posterior Root; Motoneuron Pool;
D O I
暂无
中图分类号
学科分类号
摘要
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective stimulation to the lumbosacral spinal cord with timing that coincided with the intended movement. Within one week, this spatiotemporal stimulation had re-established adaptive control of paralysed muscles during overground walking. Locomotor performance improved during rehabilitation. After a few months, participants regained voluntary control over previously paralysed muscles without stimulation and could walk or cycle in ecological settings during spatiotemporal stimulation. These results establish a technological framework for improving neurological recovery and supporting the activities of daily living after spinal cord injury.
引用
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页码:65 / 71
页数:6
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