The sirtuin SIRT6 regulates lifespan in male mice

被引:0
|
作者
Yariv Kanfi
Shoshana Naiman
Gail Amir
Victoria Peshti
Guy Zinman
Liat Nahum
Ziv Bar-Joseph
Haim Y. Cohen
机构
[1] The Mina & Everard Goodman Faculty of Life Sciences,Department of Pathology
[2] Bar-Ilan University,undefined
[3] Hadassah Medical Center and Hebrew University,undefined
[4] Lane Center for Computational Biology,undefined
[5] School of Computer Science,undefined
[6] Carnegie Mellon University,undefined
来源
Nature | 2012年 / 483卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The role of sirtuins in longevity is controversial, and little is known about mammalian sirtuins; now, male mice that overexpress SIRT6 are shown to have a longer lifespan than wild-type mice, unlike their female counterparts.
引用
收藏
页码:218 / 221
页数:3
相关论文
共 50 条
  • [1] The sirtuin SIRT6 regulates lifespan in male mice
    Kanfi, Yariv
    Naiman, Shoshana
    Amir, Gail
    Peshti, Victoria
    Zinman, Guy
    Nahum, Liat
    Bar-Joseph, Ziv
    Cohen, Haim Y.
    [J]. NATURE, 2012, 483 (7388) : 218 - 221
  • [2] Sirt6 regulates lifespan in Drosophila melanogaster
    Taylor, Jackson R.
    Wood, Jason G.
    Mizerak, Evan
    Hinthorn, Samuel
    Liu, Julianna
    Finn, Matthew
    Gordon, Sarah
    Zingas, Louis
    Chang, Chengyi
    Klein, Mark A.
    Denu, John M.
    Gorbunova, Vera
    Seluanov, Andrei
    Boeke, Jef D.
    Sedivy, John M.
    Helfand, Stephen L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (05)
  • [3] Stronger SIRT6, longer lifespan
    Neff, Ellen P.
    [J]. LAB ANIMAL, 2019, 48 (07) : 198 - 198
  • [4] Stronger SIRT6, longer lifespan
    Alexandra Le Bras
    [J]. Lab Animal, 2019, 48 : 198 - 198
  • [5] Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes
    Collins, John A.
    Kapustina, Maryna
    Bolduc, Jesalyn A.
    Pike, James F. W.
    Diekman, Brian O.
    Mix, Kimberlee
    Chubinskaya, Susan
    Eroglu, Emrah
    Michel, Thomas
    Poole, Leslie B.
    Furdui, Cristina M.
    Loeser, Richard F.
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2021, 166 : 90 - 103
  • [6] SIRTUIN 6 (SIRT6) OVEREXPRESSION REGULATES ANTIOXIDANT STATUS AND REDOX SIGNALING IN HUMAN CHONDROCYTES
    Collins, J. A.
    Pike, J. F.
    Leonard, W.
    Chubinskaya, S.
    Loeser, R. F.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2019, 27 : S51 - S51
  • [7] The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
    Jedrusik-Bode, Monika
    Studencka, Maja
    Smolka, Christian
    Baumann, Tobias
    Schmidt, Henning
    Kampf, Jan
    Paap, Franziska
    Martin, Sophie
    Tazi, Jamal
    Mueller, Kristian M.
    Krueger, Marcus
    Braun, Thomas
    Bober, Eva
    [J]. JOURNAL OF CELL SCIENCE, 2013, 126 (22) : 5166 - +
  • [8] Is nuclear sirtuin SIRT6 a master regulator of immune function?
    Pillai, Vinodkumar B.
    Gupta, Mahesh P.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2020, 320 (03): : E399 - E414
  • [9] Nuclear Sirtuin Sirt6, Protects Mice From Endotoxin-Induced Septic Cardiomyopathy
    Samant, Sadhana A.
    Pillai, Vinod Kumar Bhaskara
    Hund, Samantha
    Gupta, Madhu
    Gupta, Mahesh P.
    [J]. CIRCULATION, 2022, 146
  • [10] Sirt6 is required for spermatogenesis in mice
    Wei, Huafang
    Khawar, Muhammad Babar
    Tang, Wenhao
    Wang, Lina
    Wang, Liying
    Liu, Chao
    Jiang, Hui
    Li, Wei
    [J]. AGING-US, 2020, 12 (17): : 17099 - 17113