X-chromosome inactivation and escape

被引：0
|
作者：
CHRISTINE M. DISTECHE
JOEL B. BERLETCH
机构：
[1] University of Washington,Department of Pathology
[2] University of Washington,Department of Medicine
来源：
Journal of Genetics | 2015年 / 94卷
关键词：
X chromosome; X inactivation; escape from X inactivation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.
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页码：591 / 599
页数：8
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