Characterization of Thermo-sensitive ELP-liposome Complexes According to the Conjugation Manner

被引：0
|
作者：
Heelak Choi
Jong-In Won
机构：
[1] Hongik University,Department of Chemical Engineering
来源：
Biotechnology and Bioprocess Engineering | 2019年 / 24卷
关键词：
Elastin-like polypeptide (ELP); liposome; thermo-sensitive carrier; multi-conjugates; ELP-liposome complex;
D O I：
暂无
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学科分类号：
摘要：
Elastin-like polypeptides (ELPs) are thermoresponsive protein-based biopolymers that exhibit phase transition behavior. By conjugating them to the liposome surface, temperature-sensitive ELP-liposome complexes were generated in order to use them as chemotherapeutic agents. In this study, five different ELP-liposome complexes, consisted of three multiple-conjugates and two singleconjugates, were created, and their thermal properties were investigated according to the conjugation manner and ELP length. In addition, changes in the drug release rate from these ELP-liposome complexes caused by variations in both the lysine content and length of ELPs were explored as well.
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页码：680 / 686
页数：6
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