Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

被引：0
|
作者：
Wang Yafei
Pei Lijun
Wang Jinfeng
Zheng Xiaoying
机构：
[1] Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science,
[2] Peking University,undefined
[3] State Key Laboratory of Resources and Environmental Information System,undefined
[4] Institute of Geographic Sciences and Natural Resources Research,undefined
[5] Chinese Academy of Sciences,undefined
来源：
Journal of Human Genetics | 2012年 / 57卷
关键词：
methylenetetrahydrofolic acid reductase; MTHFR C677T; single nucleotide polymorphism; ultraviolet radiation;
D O I：
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中图分类号：
学科分类号：
摘要：
The methylenetetrahydrofolic acid reductase (MTHFR) C677T polymorphism causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. Its prevalence varies among global population. We collected data about MTHFR C677T polymorphism prevalence from epidemiology studies, as well as ultraviolet (UV) radiations and some other climatological factors from the internet. The results of the correlation and quadric regression showed that there was inverse U-shape relationship between T allele frequency and UV radiation. The explanatory power of UV radiation was stronger than latitude and all climatological factors. Our results supported the hypothesis that the distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation.
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页码：780 / 786
页数：6
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