NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

被引：0
|
作者：
Ayumu Tashiro
Vladislav M. Sandler
Nicolas Toni
Chunmei Zhao
Fred H. Gage
机构：
[1] The Salk Institute for Biological Studies,Laboratory of Genetics
[2] Norwegian University of Science and Technology,Centre for the Biology of Memory
来源：
Nature | 2006年 / 442卷
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摘要：
New neurons are continuously added to the adult brain but how this affects brain function is unclear. By developing a new single-cell gene knock-out technique, Tashiro et al. show that new neurons are selected for survival depending on their synaptic input. This provides a possible mechanism for the building of new yet consistent neuronal circuits during learning and memory. In the image above, new neurons in adult dentate gyrus are visualized by retrovirus-mediated expression of green fluorescence protein. The dentate granule and CA3 pyramidal cell layers were visualized by immunostaining for NeuN.
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页码：929 / 933
页数：4
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