Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation

被引：0
|
作者：
Minghui Chang
Xingguo Song
Xinran Geng
Xingwu Wang
Weijun Wang
Thomas C. Chen
Li Xie
Xianrang Song
机构：
[1] University of Jinan,School of Medicine and Life Sciences
[2] Shandong Academy of Medicine Science,Department of Clinical Laboratory
[3] Shandong cancer hospital affiliated to Shandong University,Shandong Provincial Key Laboratory of Radiation Oncology
[4] Shandong Academy of Medical Sciences,Departments of Neurological Surgery, and Pathology
[5] Shandong cancer hospital affiliated to Shandong University,undefined
[6] Shandong Academy of Medical Sciences,undefined
[7] Maternity & Child Care Center of Dezhou,undefined
[8] University of Southern California,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 37卷 / 1期
关键词：
TMZ-POH; Mitophagy; RAB7A; NSCLC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation
    Chang, Minghui
    Song, Xingguo
    Geng, Xinran
    Wang, Xingwu
    Wang, Weijun
    Chen, Thomas C.
    Xie, Li
    Song, Xianrang
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
  • [2] Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer
    Xingguo Song
    Li Xie
    Xingwu Wang
    Qian Zeng
    Thomas C. Chen
    Weijun Wang
    Xianrang Song
    Scientific Reports, 6
  • [3] Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer
    Song, Xingguo
    Xie, Li
    Wang, Xingwu
    Zeng, Qian
    Chen, Thomas C.
    Wang, Weijun
    Song, Xianrang
    SCIENTIFIC REPORTS, 2016, 6
  • [4] Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer
    Song, Xingguo
    Xie, Li
    Chang, Minghui
    Geng, Xinran
    Wang, Xingwu
    Chen, Thomas C.
    Song, Xianrang
    CELL DEATH & DISEASE, 2018, 9
  • [5] Temozolomide–perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer
    Xingguo Song
    Li Xie
    Minghui Chang
    Xinran Geng
    Xingwu Wang
    Thomas C. Chen
    Xianrang Song
    Cell Death & Disease, 9
  • [6] Repurposing sertraline sensitizes non-small cell lung cancer cells to erlotinib by inducing autophagy
    Jiang, Xingwu
    Lu, Weiqiang
    Shen, Xiaoyang
    Wang, Quan
    Lv, Jing
    Liu, Mingyao
    Cheng, Feixiong
    Zhao, Zhongming
    Pang, Xiufeng
    JCI INSIGHT, 2018, 3 (11)
  • [7] Papuamine Inhibits Viability of Non-small Cell Lung Cancer Cells by Inducing Mitochondrial Dysfunction
    Min, Hye-Young
    Jung, Yujin
    Park, Kwan Hee
    Lee, Ho-Young
    ANTICANCER RESEARCH, 2020, 40 (01) : 323 - 333
  • [8] miR-101-3p sensitizes non-small cell lung cancer cells to irradiation
    Li, Zhonghui
    Qu, Zhenjie
    Wang, Ying
    Qin, Meilin
    Zhang, Hua
    OPEN MEDICINE, 2020, 15 (01): : 413 - 423
  • [9] MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel
    Liu, Ronghua
    Liu, Xiaoming
    Zheng, Yijie
    Gu, Jie
    Xiong, Shudao
    Jiang, Pei
    Jiang, Xuechao
    Huang, Enyu
    Yang, Yixian
    Ge, Di
    Chu, Yiwei
    ONCOLOGY LETTERS, 2014, 8 (05) : 2193 - 2200
  • [10] Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells
    Laxmi, Yeruva
    Pierre, Keon J.
    Elegbede, Ablodun
    Wang, Robert C.
    Carper, Stephen W.
    CANCER LETTERS, 2007, 257 (02) : 216 - 226
12345