Click Synthesis of 1,2,3-Triazole Nucleosides Based on Functionalized Nicotinonitriles

被引：0
|
作者：
H. A. Morsy
S. M. Mohammed
A. M. Abdel Hamid
A. H. Moustafa
H. A. El-Sayed
机构：
[1] Higher Institution of Engineering & Modern Technology,Department of Chemistry, Faculty of Science
[2] Zagazig University,undefined
来源：
Russian Journal of Organic Chemistry | 2020年 / 56卷
关键词：
2-oxonicotinonitrile; 1,2,3-triazole; nucleosides; click reaction; antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A facile synthesis of a new series of 1,2,3-triazolyl nucleosides via one-pot click reaction is described. Acetylenic nicotinonitriles synthesized previously by alkylation of 4,6-diaryl-2-oxonicotinonitriles with propargyl bromide were involved in cycloaddition with 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl azide in the presence of copper(I) to afford 1,2,3-triazole derivatives which were deprotected by treatment with aqueous triethylamine. The obtained 1,2,3-triazole nucleosides showed significant antimicrobial activities against some Gram-positive and Gram-negative bacteria and fungi.
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页码：143 / 147
页数：4
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