Intrinsically Disordered Proteins in the Neurodegenerative Processes: Formation of Tau Protein Paired Helical Filaments and Their Analysis

被引：0
|
作者：
Rostislav Skrabana
Jozef Sevcik
Michal Novak
机构：
[1] Slovak Academy of Sciences,Institute of Neuroimmunology
[2] Axon Neuroscience Ltd.,Institute of Molecular Biology
[3] Slovak Academy of Sciences,Institute of Neuroimmunology
[4] Slovak Academy of Sciences,undefined
来源：
Cellular and Molecular Neurobiology | 2006年 / 26卷
关键词：
intrinsically disordered proteins; neurodegeneration; tau protein; Alzheimer's disease; paired helical filaments; neurofibrillary pathology; monoclonal antibody;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
1. Several intrinsically disordered proteins (IDPs) play principal role in the neurodegenerative processes of various types. Among them, α-synuclein is involved in Parkinson's disease, prion protein in transmissible spongiform encephalopathies, and tau protein in Alzheimer's disease (AD) and related tauopathies. Neuronal damage in AD is accompanied by the presence of tau protein fibrils composed of paired helical filaments (PHF).
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页码：1083 / 1095
页数：12
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