Non-B DNA structure-induced genetic instability and evolution

被引:0
|
作者
Junhua Zhao
Albino Bacolla
Guliang Wang
Karen M. Vasquez
机构
[1] The University of Texas M.D. Anderson Cancer Center,Department of Carcinogenesis, Science Park
来源
Cellular and Molecular Life Sciences | 2010年 / 67卷
关键词
Non-B DNA structures; Repetitive sequences; Genomic instability; Evolutionary change; Gene regulation;
D O I
暂无
中图分类号
学科分类号
摘要
Repetitive DNA motifs are abundant in the genomes of various species and have the capacity to adopt non-canonical (i.e., non-B) DNA structures. Several non-B DNA structures, including cruciforms, slipped structures, triplexes, G-quadruplexes, and Z-DNA, have been shown to cause mutations, such as deletions, expansions, and translocations in both prokaryotes and eukaryotes. Their distributions in genomes are not random and often co-localize with sites of chromosomal breakage associated with genetic diseases. Current genome-wide sequence analyses suggest that the genomic instabilities induced by non-B DNA structure-forming sequences not only result in predisposition to disease, but also contribute to rapid evolutionary changes, particularly in genes associated with development and regulatory functions. In this review, we describe the occurrence of non-B DNA-forming sequences in various species, the classes of genes enriched in non-B DNA-forming sequences, and recent mechanistic studies on DNA structure-induced genomic instability to highlight their importance in genomes.
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页码:43 / 62
页数:19
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