Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?

被引：0
|
作者：
Chih-Chung Shiao
Tao-Min Huang
Herbert D. Spapen
Patrick M. Honore
Vin-Cent Wu
机构：
[1] Division of Nephrology,Division of Nephrology, Department of Internal Medicine
[2] Department of Internal Medicine,ICU Department, Universitair Ziekenhuis Brussel
[3] Saint Mary’s Hospital Luodong,undefined
[4] Saint Mary’s Junior College of Medicine,undefined
[5] Nursing and Management,undefined
[6] National Taiwan University Hospital,undefined
[7] Vrije Universiteit Brussel,undefined
[8] NSARF,undefined
[9] National Taiwan University Study Group on Acute Renal Failure,undefined
来源：
Critical Care | / 21卷
关键词：
Acute kidney injury; Delayed; Early; Intensive care unit; Renal replacement therapy; Timing;
D O I：
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学科分类号：
摘要：
Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome.
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