Asymmetrically Substituted myo-Inositols. XXXIX. The Synthesis of Conjugate of 2',3'-Didehydro-3'-deoxythymidine with Phosphatidylinositol: A New Nucleoside Phospholipid with Potential Anti-HIV Activity

被引：0

作者：

N. S. Shastina

O. A. Tuchnaya

L. I. Einisman

I. I. Kashiricheva

A. E. Stepanov

A. M. Yurkevich

V. I. Shvets

机构：

[1] Lomonosov State Academy of Fine Chemical Technology,

来源：

Russian Journal of Bioorganic Chemistry | 2003年 / 29卷

关键词：

myo-inositol; phosphatidylinositol; H-phosphonate method; 2',3'-didehydro-3'-deoxythymidine; phosphoamidite method;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A partially protected phosphatidylinositol with a free hydroxyl group in the cyclitol moiety was synthesized by phosphorylation of a tetrasubstituted myo-inositol using the H-phosphonate and phosphoamidite methods. The H-phosphonate method was advantageous for the synthesis of selectively protected monophosphoinositide due to a lesser number of stages. Two schemes for the conjugation of 2',3'-didehydro-3'-de oxythymidine with phosphatidylinositol using succinic acid as a linker were tested in the synthesis of the target nucleoside phospholipid.

引用

页码：267 / 273

页数：6

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